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| Nomenclature |
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Symbol:
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Huwe1tm1Alas
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Name:
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HECT, UBA and WWE domain containing 1;
targeted mutation 1, Anna Lasorella
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MGI ID: |
MGI:4439480 |
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Synonyms: |
Huwe1flox |
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Gene:
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Huwe1
Location:
ChrX:151800807-151935417 bp, + strand
Genetic Position: ChrX,
68.46 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:152966
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The allele was created by inserting an FRT-flanked pGKNeoR cassette into intron 82 and loxP sites into intron 79 and 82. Exons 80-82 encode most of the HECT domain of Huwe1. (J:145660)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Huwe1 Mutation:
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53 strains or lines available |
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| References |
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Original: |
J:145660
Zhao X et al.,
"The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein."
Nat Cell Biol 2008 Jun;10(6):643-53
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All: |
3 reference(s)
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Analysis Tools
