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| Nomenclature |
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Symbol:
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Srrtm1.2Jtc
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Name:
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serine racemase;
targeted mutation 1.2, Joseph T Coyle
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MGI ID: |
MGI:4438917 |
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Synonyms: |
SR- |
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Gene:
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Srr
Location:
Chr11:74906509-74925948 bp, - strand
Genetic Position: Chr11,
45.76 cM, cytoband B4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:158266
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP-flanked neomycin phosphotransferase cassette was inserted with intron 1 and another loxP sequence 5' to exon 1 by homologous recombination. The selection cassette and exon 1 were removed by cre mediated recombination. Absence of protein was confirmed by western blot of whole brain extracts. (J:158266)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Srr Mutation:
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17 strains or lines available |
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| References |
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Original: |
J:158266
Basu AC et al.,
"Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior."
Mol Psychiatry 2009 Jul;14(7):719-27
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All: |
7 reference(s)
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Analysis Tools
