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| Nomenclature |
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Symbol:
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Tg(Thy1-AppDutch)#Jckr
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Name:
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transgene insertion, Mathias Jucker
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MGI ID: |
MGI:4438890 |
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Transgene:
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Tg(Thy1-AppDutch)#Jckr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A human APP751 cDNA with a mutation in the codon for amino acid residue 693 causing a glutamic acid to glutamine change (E693Q) was place under the control of the murine Thy1.2 minigene. Five positive founder mice were identified. This record is for combined data from the two highest expressing lines, lines 23 and 33. Epression is five times higher than for endogenous APP. (J:92796)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:92796
Herzig MC et al.,
"Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis."
Nat Neurosci 2004 Sep;7(9):954-60
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All: |
6 reference(s)
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Analysis Tools
