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| Nomenclature |
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Symbol:
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Tg(Lrrk2*G2019S)2Yue
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Name:
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transgene insertion 2, Zhenyu Yue
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MGI ID: |
MGI:4437428 |
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Synonyms: |
FLAG-LRRK2-G2019S |
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Transgene:
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Tg(Lrrk2*G2019S)2Yue
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x C3H)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A bacterial artificial chromosome (BAC) (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the Lrrk2 locus to harbor the Lrrk2-G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. This modified 240 kb BAC contains a FLAG-tag downstream from the start codon. Line 2 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2. (J:128036)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:128036
Li X et al.,
"Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants."
J Neurochem 2007 Oct;103(1):238-47
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All: |
2 reference(s)
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Analysis Tools
