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| Nomenclature |
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Symbol:
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Irs1tm2.1Mfw
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Name:
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insulin receptor substrate 1;
targeted mutation 2.1, Morris F White
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MGI ID: |
MGI:4430350 |
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Gene:
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Irs1
Location:
Chr1:82233101-82291416 bp, - strand
Genetic Position: Chr1,
42.0 cM, cytoband C5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:156999
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A point mutation changing Ser 307 to Ala and a floxed Neo cassette placed immediately after the stop codon were insertedby homologous recombination. The neo has been removed by cre-mediated recombination. A residual 66 bp, includes a loxP site, remains in the 3' noncoding region. (J:156999)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irs1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:156999
Copps KD et al.,
"Irs1 serine 307 promotes insulin sensitivity in mice."
Cell Metab 2010 Jan;11(1):84-92
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All: |
1 reference(s)
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Analysis Tools
