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| Nomenclature |
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Symbol:
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Themis5AT161
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Name:
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thymocyte selection associated;
5AT161
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MGI ID: |
MGI:4353412 |
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Synonyms: |
Themis(Y489X) |
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Gene:
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Themis
Location:
Chr10:28668360-28883818 bp, + strand
Genetic Position: Chr10,
16.06 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: A T-to-A transversion generated a stop codon in place of the sequence encoding a tyrosine residue at position 489. Immunoblot analysis on homozygote thymus extracts detected only a very small amount of truncated protein, and mRNA levels in these extracts were one-third of endogenous levels. (J:151076)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Themis Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:151076
Johnson AL et al.,
"Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection."
Nat Immunol 2009 Aug;10(8):831-9
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All: |
1 reference(s)
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Analysis Tools
