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| Nomenclature |
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Symbol:
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Themistm1Gasc
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Name:
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thymocyte selection associated;
targeted mutation 1, Nicholas R J Gascoigne
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MGI ID: |
MGI:4353091 |
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Synonyms: |
Themis- |
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Gene:
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Themis
Location:
Chr10:28668360-28883818 bp, + strand
Genetic Position: Chr10,
16.06 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:151074
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Parent Cell Line:
| CMTI-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin cassette replaced exon 1 of the gene locus. Gene inactivation was confirmed by a lack of protein detected in immunoblot assays of homozygote thymus extract. (J:151074)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:151074
Fu G et al.,
"Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling."
Nat Immunol 2009 Aug;10(8):848-56
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All: |
1 reference(s)
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Analysis Tools
