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| Nomenclature |
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Symbol:
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Tg(LRRK2*R1441G)135Cjli
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Name:
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transgene insertion 135, Chenjian Li
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MGI ID: |
MGI:3847811 |
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Synonyms: |
LRRK2R1441G, TG-RP135 |
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Transgene:
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Tg(LRRK2*R1441G)135Cjli
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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FVB/NTac
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A human bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 188 kb BAC containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene with 29 kb upstream of the LRRK2 start codon and 42 kb downstream of the LRRK2 stop codon. Bioinformatics analysis predicted that no other genes are present in the BAC. This BAC was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2 R1441G (4321C>G) mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. (J:149135)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:149135
Li Y et al.,
"Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease."
Nat Neurosci 2009 Jun 7;12(7):826-8
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All: |
3 reference(s)
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Analysis Tools
