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| Nomenclature |
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Symbol:
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Cisd2tm1Tfts
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Name:
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CDGSH iron sulfur domain 2;
targeted mutation 1, Ting-Fen Tsai
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MGI ID: |
MGI:3846404 |
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Gene:
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Cisd2
Location:
Chr3:135406412-135423925 bp, - strand
Genetic Position: Chr3,
62.55 cM, cytoband H2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:148467
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Duplication |
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Mutation details: The genomic sequence extending from the 3' end of intron 1 through the 5' end of exon 3 was replaced with the missing portion of intron 1 through the 5' end of exon 3 following by a puromycin resistance cassette, loxP site, 3'Hprt mini-gene, and a duplication of the 3' end of intron 1 through the 5' end of exon 3. The absence of transcript expression was confirmed by northern blot analysis on brain extracts. (J:148467)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cisd2 Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:148467
Chen YF et al.,
"Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice."
Genes Dev 2009 May 15;23(10):1183-94
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All: |
1 reference(s)
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Analysis Tools
