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| Nomenclature |
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Symbol:
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Avptm1Lja
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Name:
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arginine vasopressin;
targeted mutation 1, J Larry Jameson
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MGI ID: |
MGI:3843457 |
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Synonyms: |
AvpC67X |
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Gene:
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Avp
Location:
Chr2:130580620-130582554 bp, - strand
Genetic Position: Chr2,
63.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:148012
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: A floxed neo cassette was inserted in intron 1 and a C67X nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. RT-PCR confirmed the expression of mutant transcript in the hypothalamus. (J:148012)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Avp Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:148012
Russell TA et al.,
"A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons."
J Clin Invest 2003 Dec;112(11):1697-706
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All: |
1 reference(s)
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Analysis Tools
