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| Nomenclature |
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Symbol:
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Avptm1Hari
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Name:
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arginine vasopressin;
targeted mutation 1, Hiroshi Arima
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MGI ID: |
MGI:3843456 |
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Gene:
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Avp
Location:
Chr2:130580620-130582554 bp, - strand
Genetic Position: Chr2,
63.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:147993
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: A floxed pgk-neo cassette was inserted in intron 2 and a Cys98stop nonsense mutation was inserted in exon 2 via homologous recombination. The floxed neo cassette was then removed by Cre mediated recombination. Immunohistochemical analysis detected expression of a mutant protein in the supraoptic nucleus, the suprachiasmatic nuclei, and the paraventricular nucleus in homozygous and heterozygous mice. This analysis also confirmed the absence of wild-type protein expression in homozygous mice. (J:147993)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Avp Mutation:
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24 strains or lines available |
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| References |
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Original: |
J:147993
Hayashi M et al.,
"Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus."
Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1641-9
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All: |
3 reference(s)
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Analysis Tools
