|
|
| Nomenclature |
|
Symbol:
|
Foxo1tm1Flv
|
|
Name:
|
forkhead box O1;
targeted mutation 1, Richard A Flavell
|
|
MGI ID: |
MGI:3840910 |
|
Synonyms: |
Foxo1flox |
|
Gene:
|
Foxo1
Location:
Chr3:52268337-52350109 bp, + strand
Genetic Position: Chr3,
23.19 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:147057
|
|
Parent Cell Line:
| TC1/TC-1 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A loxP site was inserted into the XbaI restriction site upstream of exon 1 and a frt-flanked neoymycin cassette with a 3' loxP site was inserted downstream of exon 1. Mice were crossed with transgenic Flipase to remove the neomycin cassette, leaving exon 1 floxed. Protein expression was unaffected as determined by immunoblot analysis of homozygote lymphocyte extracts. (J:147057)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Foxo1 Mutation:
|
4 strains or lines available |
|
| References |
|
Original: |
J:147057
Ouyang W et al.,
"An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance."
Immunity 2009 Mar;30(3):358-71
|
|
All: |
3 reference(s)
|
|
Analysis Tools
