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| Nomenclature |
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Symbol:
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Tg(tetO-DISC1*)1001Plet
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Name:
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transgene insertion 1001, Mikhail Pletnikov
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MGI ID: |
MGI:3838645 |
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Synonyms: |
Tg(tetO/CMV-DISC1*)1001Plet, Tg(TRE-CMVhDISC1) |
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Transgene:
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Tg(tetO-DISC1*)1001Plet
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 and SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct was designed with the myc peptide tagged mutant human DISC1 (disrupted in schizophrenia 1) gene, under the control of tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequence and a cytomegalovirus minimal promoter. Founder line 1001, which showed strong expression, was established. A second line, line 70, shows weak expression of human DISC1. (J:146881)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:146881
Pletnikov MV et al.,
"Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia."
Mol Psychiatry 2008 Feb;13(2):173-86, 115
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All: |
3 reference(s)
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Analysis Tools
