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| Nomenclature |
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Symbol:
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Col1a1tm2(CAG-EGFR*)Char
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Name:
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collagen, type I, alpha 1;
targeted mutation 2, Al Charest
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MGI ID: |
MGI:3837826 |
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Synonyms: |
Col1alpha1-EGFRvIII |
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Gene:
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Col1a1
Location:
Chr11:94936224-94953042 bp, + strand
Genetic Position: Chr11,
59.01 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146494
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A CAG promoter was used to drive expression the oncogenic variant vIII of human EGFR with an intervening floxed STOP cassette inserted into the 3' untranslated region. The mutant form contains an in-frame deletion of exons 2 through 7 and codes for a ligand independent receptor. (J:146494)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Col1a1 Mutation:
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64 strains or lines available |
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| References |
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Original: |
J:146494
Zhu H et al.,
"Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis."
Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2712-6
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All: |
1 reference(s)
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Analysis Tools
