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| Nomenclature |
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Symbol:
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Tg(Prnp*D177N*M128V)A21Rchi
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Name:
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transgene insertion A21, Roberto Chiesa
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MGI ID: |
MGI:3836986 |
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Synonyms: |
CJD-A21, moPrP D177N/V128, Tg(CJD), Tg(CJD-A21) |
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Transgene:
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Tg(Prnp*D177N*M128V)A21Rchi
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/J)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Site directed mutagenesis was used to generate a murine Prnp gene homologous to the D178N/V129 human variants linked to Creutzfeldt-Jakob disease. Five founder lines were created with this line containing 22 copies of the transgene. Transgenic protein levels in hemizygote brain were similar to endogenous protein levels, with about 50% of transgenic protein being insoluble. (J:142098)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:142098
Dossena S et al.,
"Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model."
Neuron 2008 Nov 26;60(4):598-609
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All: |
3 reference(s)
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Analysis Tools
