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| Nomenclature |
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Symbol:
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Egr2tm2Jmi
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Name:
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early growth response 2;
targeted mutation 2, Jeffrey Milbrandt
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MGI ID: |
MGI:3836632 |
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Synonyms: |
Egr2I26N |
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Gene:
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Egr2
Location:
Chr10:67535475-67542188 bp, + strand
Genetic Position: Chr10,
34.96 cM, cytoband B5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:145949
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A point mutation was used to engineer the amino acid substitution of asparagine for isoleucine at position 268 (I268N). A floxed neo cassette was inserted into the intron upstream of the point mutation and was removed by germ line, cre mediated recombination. (J:145949)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Egr2 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:145949
Baloh RH et al.,
"Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation."
J Neurosci 2009 Feb 25;29(8):2312-21
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All: |
1 reference(s)
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Analysis Tools
