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| Nomenclature |
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Symbol:
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Slitrk1tm1Jaru
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Name:
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SLIT and NTRK-like family, member 1;
targeted mutation 1, Jun Aruga
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MGI ID: |
MGI:3834477 |
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Gene:
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Slitrk1
Location:
Chr14:108909991-108914239 bp, - strand
Genetic Position: Chr14,
56.78 cM, cytoband E3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:145441
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was designed to delete 2.5 kb of the exon containing entire open-reading frame. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Western blot of mutant brain samples showed no bands corresponding to Slitrk1 protein. (J:145441)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slitrk1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:145441
Katayama K et al.,
"Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities."
Mol Psychiatry 2008 Sep 16;():
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All: |
1 reference(s)
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Analysis Tools
