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| Nomenclature |
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Symbol:
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Tg(tetO-PIK3CA*H1047R)13Lca
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Name:
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transgene insertion 13, Lewis C Cantley
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MGI ID: |
MGI:3834439 |
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Synonyms: |
p110-alpha H1047R |
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Transgene:
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Tg(tetO-PIK3CA*H1047R)13Lca
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The tetracyclin operator was used to drive expression of the human cDNA with a point mutation that results in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Three lines were generated (13, 121 and 3011). Line 13 carries around 20 copies of the transgene compared to around 60 in line 121. (J:142254)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:142254
Engelman JA et al.,
"Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers."
Nat Med 2008 Dec;14(12):1351-6
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All: |
1 reference(s)
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Analysis Tools
