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| Nomenclature |
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Symbol:
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Myh11tm2Peri
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Name:
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myosin, heavy polypeptide 11, smooth muscle;
targeted mutation 2, Muthu Periasamy
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MGI ID: |
MGI:3821724 |
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Synonyms: |
SM2- |
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Gene:
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Myh11
Location:
Chr16:14194527-14291408 bp, - strand
Genetic Position: Chr16,
9.71 cM
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Myh11tm2Peri/Myh11tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:142230
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 41 was replaced with a neo cassette. The absence of isoform SM2 and reduced presence of isoform SM1 was confirmed by western blot analysis on bladder extracts. (J:142230)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Myh11 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:142230
Chi M et al.,
"Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice."
Proc Natl Acad Sci U S A 2008 Nov 25;105(47):18614-8
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All: |
1 reference(s)
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Analysis Tools
