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| Nomenclature |
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Symbol:
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Airetm2Mmat
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Name:
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autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy);
targeted mutation 2, Mitsuru Matsumoto
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MGI ID: |
MGI:3818933 |
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Synonyms: |
Airegfp |
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Gene:
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Aire
Location:
Chr10:78030022-78043610 bp, - strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141379
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Genomic sequence from immediately after the Kozak sequence in exon 1 to the exon 2 was replaced with GFP and a floxed neo cassette via homologous recombination. The neo cassette was removed via in vivo Cre mediated recombination. Immunohistochemical analysis in heterozygous mice indicates that the pattern of GFP expression is similar to the pattern of endogenous gene expression. (J:141379)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:141379
Yano M et al.,
"Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance."
J Exp Med 2008 Nov 24;205(12):2827-38
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All: |
3 reference(s)
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Analysis Tools
