|
|
| Nomenclature |
|
Symbol:
|
Tc(HSA21)1TybEmcf
|
|
Name:
|
transchromosomal, human 21, line 1, Victor Tybulewicz and Elizabeth M C Fisher
|
|
MGI ID: |
MGI:3814712 |
|
Synonyms: |
Tc1, Tc(HSA21)91-1Emcf |
|
Gene:
|
Tc(Hsa21)1TybEmcf
Location:
unknown
|
|
Mutation
origin |
|
Mutant Cell Line:
| 91-1 (Not Specified) |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:101383
|
|
Parent Cell Line:
| Other (see notes) (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Not Applicable |
|
Mutation: | |
Other |
| |
|
Mutation details: A freely segregating chromosome composed of 42 Mb, or 90%, of human chromosome 21 (spanning D21S5-CXADR, D21S1922-IFNAR1 and RUNX1-COL6A1) was created in MPI-VI (129S2/SvPas) ES cells using irradiated microcell-mediated chromosome transfer. (J:101383)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
|
Notes |
ES cell line = MPI-VI.
|
| References |
|
Original: |
J:101383
O'Doherty A et al.,
"An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes."
Science 2005 Sep 23;309(5743):2033-7
|
|
All: |
11 reference(s)
|
|
Analysis Tools
