|
|
| Nomenclature |
|
Symbol:
|
Tg(MT1A-Dyrk1a)#Xest
|
|
Name:
|
transgene insertion #, Xavier Estivill
|
|
MGI ID: |
MGI:3814575 |
|
Synonyms: |
TgDyrk1A |
|
Transgene:
|
Tg(MT1A-Dyrk1a)#Xest
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
C57BL/6 x SJL
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The sheep promoter was used to drive expression of the full-length rat gene in the brain, heart and liver. Four lines were created (lines 9, 28, 31 and 33) that carry 2 to 20 copies of the transgene (2, 2, 20 and 5 copies, respectively). (J:71821)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:71821
Altafaj X et al.,
"Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome."
Hum Mol Genet 2001 Sep 1;10(18):1915-23
|
|
All: |
2 reference(s)
|
|
Analysis Tools
