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| Nomenclature |
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Symbol:
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Tg(Prnp-Abca1)EHol
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Name:
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transgene insertion E, David M Holtzman
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MGI ID: |
MGI:3800823 |
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Synonyms: |
PrP-mAbca1 line E |
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Transgene:
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Tg(Prnp-Abca1)EHol
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter was injected into fertilized B6CBAF1 eggs. Founder line E was subsequently established. These founder line E mice have a 6-fold increase in expression of ABCA1 in the cortex over wildtype levels. Transgene expression is high in total brain tissue, kidney, testis and muscle as detected by Western blot analysis. (J:131400)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:131400
Wahrle SE et al.,
"Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease."
J Clin Invest 2008 Feb;118(2):671-82
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All: |
1 reference(s)
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Analysis Tools
