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| Nomenclature |
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Symbol:
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Alox12btm1.1Krie
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Name:
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arachidonate 12-lipoxygenase, 12R type;
targeted mutation 1.1, Peter Krieg
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MGI ID: |
MGI:3795936 |
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Gene:
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Alox12b
Location:
Chr11:69156989-69169792 bp, + strand
Genetic Position: Chr11,
42.38 cM
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Impaired epidermal barrier in Alox12btm1.1Krie/Alox12btm1.1Krie mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134709
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Heterozygous Alox12btm1Krie mice was crossed with deleter mice expressing Cre recombinase resulting in excision of the tk/neo selection cassette and exon 8. The mutated RNA expression was confirmed by RT-PCR, however, no protein product was detected by Western blot. (J:134709)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Alox12b Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:134709
Epp N et al.,
"12R-lipoxygenase deficiency disrupts epidermal barrier function."
J Cell Biol 2007 Apr 9;177(1):173-82
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All: |
2 reference(s)
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Analysis Tools
