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| Nomenclature |
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Symbol:
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Mirc1tm1.2Tyj
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Name:
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microRNA cluster 1, including Mir17 through Mir92-1;
targeted mutation 1.2, Tyler Jacks
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MGI ID: |
MGI:3790968 |
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Synonyms: |
miR-17~92delta, Mirn17-92tm1.2Tyj |
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Gene:
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Mirc1
Location:
Chr14:115043671-115044506 bp
Genetic Position: Chr14,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134861
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intergenic deletion |
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Mutation details: Crossing Mirc1tm1.1Tyj mice to a Cre deleter strain (human ACTB beta actin promoter) excised the floxed cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1. This results in a null allele. (J:134861)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:134861
Ventura A et al.,
"Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters."
Cell 2008 Mar 7;132(5):875-86
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All: |
5 reference(s)
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Analysis Tools
