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| Nomenclature |
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Symbol:
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Brca1tm1Thl
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Name:
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breast cancer 1;
targeted mutation 1, Thomas Ludwig
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MGI ID: |
MGI:3790741 |
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Synonyms: |
Brca1flex2 |
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Gene:
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Brca1
Location:
Chr11:101488764-101551955 bp, - strand
Genetic Position: Chr11,
65.18 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134977
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An frt-flanked neo cassette with a 3' neo cassette was inserted upstream of exon 2 and an additional neo cassette was inserted downstream of exon 2. This exon encodes most of the RING finger domain. (J:134977)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Brca1 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:134977
Shakya R et al.,
"The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression."
Proc Natl Acad Sci U S A 2008 May 13;105(19):7040-5
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All: |
2 reference(s)
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Analysis Tools
