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| Nomenclature |
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Symbol:
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Tg(Thy1-SOD1*G93A)T3Hgrd
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Name:
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transgene insertion T3, Casper Hoogenraad
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MGI ID: |
MGI:3785090 |
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Synonyms: |
Thy1.2-G93A |
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Transgene:
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Tg(Thy1-SOD1*G93A)T3Hgrd
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain adn spinal cord was determined by Western blot. Line T3 was characterized further. (J:134095)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:134095
Jaarsma D et al.,
"Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice."
J Neurosci 2008 Feb 27;28(9):2075-88
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All: |
1 reference(s)
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Analysis Tools
