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| Nomenclature |
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Symbol:
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Rspo1tm1.1Ktom
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Name:
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R-spondin homolog (Xenopus laevis);
targeted mutation 1.1, Kazuma Tomizuka
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MGI ID: |
MGI:3784965 |
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Gene:
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Rspo1
Location:
Chr4:124986430-125009099 bp, + strand
Genetic Position: Chr4,
57.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:133934
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele was made using sequential targeting events. The first targeting event resulted in the insertion of a floxed neo cassette into exon 2 and the second event resulted in the replacement of exons 5 through 6 with a floxed puromycin resistance cassette. Transient cre expression was used to remove the selection cassettes and the remaining coding region of exon 2 and exon 3. The final allele lacks the entire coding region. The absence of transcript was confirmed by RT-PCR on ovary and testis extracts. (J:133934)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rspo1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:133934
Tomizuka K et al.,
"R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling."
Hum Mol Genet 2008 May 1;17(9):1278-91
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All: |
1 reference(s)
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Analysis Tools
