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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT*P301S)2541Godt
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Name:
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transgene insertion 2541, Michel Goedert
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MGI ID: |
MGI:3778191 |
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Synonyms: |
TauP301S |
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Transgene:
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Tg(Thy1-MAPT*P301S)2541Godt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/Ca)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The neuron-specific promoter elements of the mouse Thy1 gene drive expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats - in which proline is replaced by serine at amino acid position 301 of the protein (P301S). Immunoblot analysis demonstrates the presence of human tau at approximately twice the level of the combined endogenous mouse tau proteins in brains and spinal cords of 5-6 month old homozygous transgenic mice. (J:108870)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Homozygous transgenic lines were established from three founder mice. The data reported were obtained using mice of line 2541. (J:108870)
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| References |
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Original: |
J:108870
Allen B et al.,
"Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein."
J Neurosci 2002 Nov 1;22(21):9340-51
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All: |
13 reference(s)
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Analysis Tools
