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| Nomenclature |
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Symbol:
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Eya4tm1Jse
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Name:
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eyes absent 4 homolog (Drosophila);
targeted mutation 1, Jonathan G Seidman
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MGI ID: |
MGI:3775095 |
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Gene:
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Eya4
Location:
Chr10:23104168-23349895 bp, - strand
Genetic Position: Chr10,
10.44 cM
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Middle ear pathology shows that Eya4tm1Jse/Eya4tm1Jse mice develop otitis media
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:131873
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 8 and all of exons 9 and 10 were replaced with a neo/zeocin cassette. The absence of transcript was confirmed by RT-PCR in cardiac extracts. (J:131873)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Eya4 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:131873
Depreux FF et al.,
"Eya4-deficient mice are a model for heritable otitis media."
J Clin Invest 2008 Feb;118(2):651-8
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All: |
1 reference(s)
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Analysis Tools
