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| Nomenclature |
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Symbol:
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Toxtm1.1Kay
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Name:
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thymocyte selection-associated high mobility group box;
targeted mutation 1.1, Jonathan Kaye
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MGI ID: |
MGI:3773716 |
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Gene:
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Tox
Location:
Chr4:6686353-6991557 bp, - strand
Genetic Position: Chr4,
3.04 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:131287
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Parent Cell Line:
| CMTI-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient expression of cre recombinase removed the neo cassette and exon 1. The absence of protein product was confirmed by western blot analysis on total thymocyte extracts. (J:131287)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tox Mutation:
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1 strain or line available |
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| References |
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Original: |
J:131287
Aliahmad P et al.,
"Development of all CD4 T lineages requires nuclear factor TOX."
J Exp Med 2008 Jan 21;205(1):245-56
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All: |
2 reference(s)
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Analysis Tools
