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| Nomenclature |
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Symbol:
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Del(11Mpo-Chad)18Brd
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Name:
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deletion, Chr 11, Bradley 18;
deletion, Chr 11, Allan Bradley 18
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MGI ID: |
MGI:3766573 |
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Synonyms: |
Del18Brd, Df(11)18 |
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Gene:
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Del(11Mpo-Chad)18Brd
Location:
unknown
Genetic Position: Chr11,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:109163
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intergenic deletion |
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Mutation details: A loxP site was targeted into the Mpo gene. A second loxP site was targeted in trans into the Chad gene. Transient expression of Cre recombinase in ES cells resulted in recombination between loxP sites on opposite chromosomes, deleting the 6.9 Mb region from Mpo to Chad. (J:109163)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:109163
Yu YE et al.,
"A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice."
Genetics 2006 May;173(1):297-307
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All: |
1 reference(s)
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Analysis Tools
