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| Nomenclature |
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Symbol:
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Mc2rtm1Dchi
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Name:
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melanocortin 2 receptor;
targeted mutation 1, Dai Chida
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MGI ID: |
MGI:3764974 |
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Synonyms: |
MC2R- |
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Gene:
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Mc2r
Location:
Chr18:68406907-68429251 bp, - strand
Genetic Position: Chr18,
41.89 cM
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Histological analysis of the adrenal gland of Mc2rtm1Dchi/Mc2rtm1Dchi mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:127445
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding region contained within exon 4 was replaced with a PGK-neo cassette. RT-PCR confirmed the absence of transcript in extracts from the adrenal gland. (J:127445)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:127445
Chida D et al.,
"Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis."
Proc Natl Acad Sci U S A 2007 Nov 13;104(46):18205-10
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All: |
3 reference(s)
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Analysis Tools
