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| Nomenclature |
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Symbol:
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Tg(Th-SNCA*)1Mgsp
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Name:
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transgene insertion 1, Maria Grazia Spillantini
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MGI ID: |
MGI:3758646 |
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Synonyms: |
TgSyn120 |
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Transgene:
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Tg(Th-SNCA*)1Mgsp
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the rat tyrosine hydroxylase promoter Th in an expression vector. Vector sequences were removed and the linearized construct was microinjected into fertilized eggs. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Immunoblotting demostrated high levels of alpha-synuclein 1-120 in the nigrostriatal pathway and the olfactory bulb in the line 1 founder. (J:108310)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:108310
Tofaris GK et al.,
"Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders."
J Neurosci 2006 Apr 12;26(15):3942-50
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All: |
3 reference(s)
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Analysis Tools
