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| Nomenclature |
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Symbol:
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Tg(Th-SNCA*)1702Yosh
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Name:
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transgene insertion 1702, Makoto Yoshimoto
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MGI ID: |
MGI:3757756 |
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Synonyms: |
syn130m, Syn130m-1702 |
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Transgene:
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Tg(Th-SNCA*)1702Yosh
Location:
unknown
Genetic Position: Chr8,
cytoband B3
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x C3H)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct contains the human alpha synuclein sequence with an A53T point mutation and a stop codon engineered at residue 130 which results in a truncated protein lacking the last 10 amino acids at the C-terminus. This sequence is under control of the rat tyrosine hydroxylase (Th) promoter (9 kb of 5' flanking region of the rat Th gene). The purified construct was injected into pronuclei of fertilized (C57BL/6 x C3H)F1 eggs. Copy number is estimated to be ~30. Expression of the transgene product is detected in the midbrain in soma and axons of neurons in the substantia nigra pars compacta. (J:125149)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:125149
Wakamatsu M et al.,
"Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice."
Neurobiol Aging 2008 Apr;29(4):574-85
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All: |
1 reference(s)
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Analysis Tools
