|
|
| Nomenclature |
|
Symbol:
|
Tg(PDGFB-APPInd)H6Lms
|
|
Name:
|
transgene insertion H6, Lennart Mucke
|
|
MGI ID: |
MGI:3717672 |
|
Synonyms: |
APPInd, PDGF-hAPP line 6, PDGF-hAPP line H6, Tg(PDGFB-APP*V717F)H6Lms |
|
Transgene:
|
Tg(PDGFB-APPInd)H6Lms
Location:
unknown
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The transgene contains a human APP minigene encoding the Indiana mutation (V717F) which is associated with familial Alzheimer disease. The construct contained APP introns 6-8, allowing alternative splicing of exons 7 and 8. The human PDGF beta-chain promoter drives expression, and the construct also contains the SV40 polyadenylation signal. Amyloid-beta ELISA on whole brain homogenates indicates higher cerebral beta-amyloid production than in Tg(APPV717F)109Ili mice expressing the same construct. (J:100980, J:102272)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:102272
Wyss-Coray T et al.,
"Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease."
Nature 1997 Oct 9;389(6651):603-6
|
|
All: |
4 reference(s)
|
|
Analysis Tools
