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| Nomenclature |
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Symbol:
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Abca3tm1Holz
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 3;
targeted mutation 1, Andreas Holzinger
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MGI ID: |
MGI:3716562 |
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Synonyms: |
Abca3- |
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Gene:
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Abca3
Location:
Chr17:24351950-24410201 bp, + strand
Genetic Position: Chr17,
12.38 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:122736
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Parent Cell Line:
| IDG3.2 (ES Cell) |
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Strain of Origin:
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(C57BL/6J x 129S6/SvEvTac)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exons 5 and 7 and all of exon 6 was replaced by an IRES-hrGFP-neo cassette. Absence of protein was confirmed by immunohistochemistry of mutant lung tissue. (J:122736)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:122736
Hammel M et al.,
"Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies."
Biochem Biophys Res Commun 2007 Aug 10;359(4):947-951
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All: |
1 reference(s)
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Analysis Tools
