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| Nomenclature |
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Symbol:
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Nfixtm1Aes
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Name:
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nuclear factor I/X;
targeted mutation 1, Albrecht E Sippel
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MGI ID: |
MGI:3714028 |
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Synonyms: |
Nfix-, NfixlacZ |
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Gene:
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Nfix
Location:
Chr8:84699876-84800344 bp, - strand
Genetic Position: Chr8,
41.02 cM, cytoband C1-C2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:122250
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was designed to replace all but the first 4 bp of exon 2 with a lacZ-loxP-neo-loxP cassette. Transient cre expression removed the neo in ES cells. RT-PCR confirmed absence of transcript in mutant brain, liver and lung samples. (J:122250)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfix Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:122250
Driller K et al.,
"Nuclear factor I X deficiency causes brain malformation and severe skeletal defects."
Mol Cell Biol 2007 May;27(10):3855-3867
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All: |
1 reference(s)
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Analysis Tools
