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| Nomenclature |
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Symbol:
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Abca3tm1Nina
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 3;
targeted mutation 1, Nobuya Inagaki
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MGI ID: |
MGI:3709991 |
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Synonyms: |
Abca3- |
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Gene:
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Abca3
Location:
Chr17:24351950-24410201 bp, + strand
Genetic Position: Chr17,
12.38 cM, cytoband A3.3
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Lung abnormalities in Abca3tm1Nina/Abca3tm1Nina mice, including pulmonary congestion and atelectasis
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121155
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A pgk-neo cassette was inserted to replace a 2948-bp fragment containing the four exons encoding the first nucleotide-binding domain. Absence of protein was confirmed by immunoblot of mutant lung tissue. (J:121155)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abca3 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:121155
Ban N et al.,
"ABCA3 as a lipid transporter in pulmonary surfactant biogenesis."
J Biol Chem 2007 Mar 30;282(13):9628-34
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All: |
1 reference(s)
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Analysis Tools
