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| Nomenclature |
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Symbol:
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Tg(Pax8-rtTA2S*M2)1Koes
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Name:
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transgene insertion 1, Robert Koesters
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MGI ID: |
MGI:3709326 |
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Synonyms: |
Pax8-rtTA |
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Transgene:
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Tg(Pax8-rtTA2S*M2)1Koes
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: he Pax8-rtTA construct contains an optimized rtTA variant (rtTA2s-M2) cDNA and SV40 polyA sequence replaced at the endogenous ATG translational start site of a murine Pax8 sequence. The rtTA2S*M2 variant contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain, resulting in reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:140925)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Phenotypic Similarity to Human Syndrome: adult onset polycystic kidney disease in mice hemizygous for Tg(Pax8-rtTA2S*M2)1Koes and Tg(tetO-MYC)36aBop (J:1409250)
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| References |
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Original: |
J:140925
Traykova-Brauch M et al.,
"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice."
Nat Med 2008 Sep;14(9):979-84
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All: |
7 reference(s)
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Analysis Tools
