|
|
| Nomenclature |
|
Symbol:
|
Sh3bp2tm1Bjro
|
|
Name:
|
SH3-domain binding protein 2;
targeted mutation 1, Bjorn R Olsen
|
|
MGI ID: |
MGI:3698401 |
|
Gene:
|
Sh3bp2
Location:
Chr5:34525838-34563625 bp, + strand
Genetic Position: Chr5,
17.89 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:117880
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Nucleotide substitutions |
| |
|
Mutation details: A proline to arginine mutation was inserted into exon 9. A floxed neo included in the vector was subsequently removed from the locus. (J:117880)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Sh3bp2 Mutation:
|
2 strains or lines available |
|
| References |
|
Original: |
J:117880
Ueki Y et al.,
"Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice."
Cell 2007 Jan 12;128(1):71-83
|
|
All: |
5 reference(s)
|
|
Analysis Tools
