|
|
| Nomenclature |
|
Symbol:
|
Agertm1.1Hyam
|
|
Name:
|
advanced glycosylation end product-specific receptor;
targeted mutation 1.1, Hiroshi Yamamoto
|
|
MGI ID: |
MGI:3692766 |
|
Synonyms: |
Rage- |
|
Gene:
|
Ager
Location:
Chr17:34597862-34600934 bp, + strand
Genetic Position: Chr17,
18.18 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:116040
|
|
Parent Cell Line:
| E14.1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: Exons 1 and 2 were removed via transient cre-mediated recombination. Western blot of mutant lung and kidney confirm absence of protein in mutants. (J:116040)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ager Mutation:
|
4 strains or lines available |
|
| References |
|
Original: |
J:116040
Myint KM et al.,
"RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin."
Diabetes 2006 Sep;55(9):2510-22
|
|
All: |
9 reference(s)
|
|
Analysis Tools
