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| Nomenclature |
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Symbol:
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Dnase2atm2Osa
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Name:
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deoxyribonuclease II alpha;
targeted mutation 2, Shigekazu Nagata
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MGI ID: |
MGI:3691118 |
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Synonyms: |
DNase IIflox |
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Gene:
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Dnase2a
Location:
Chr8:84908560-84922915 bp, + strand
Genetic Position: Chr8,
41.31 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:114982
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
| |
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Exons 3-5 were flanked with loxP sites. (J:114982)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:114982
Kawane K et al.,
"Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages."
Nature 2006 Oct 26;443(7114):998-1002
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All: |
3 reference(s)
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Analysis Tools
