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| Nomenclature |
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Symbol:
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Atg5tm1Myok
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Name:
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autophagy related 5;
targeted mutation 1, Minesuke Yokoyama
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MGI ID: |
MGI:3663625 |
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Synonyms: |
Atg5flox |
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Gene:
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Atg5
Location:
Chr10:44268358-44364291 bp, + strand
Genetic Position: Chr10,
23.24 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:110050
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to flank exon 3 with loxP sites. A neomycin resistance cassette was included such that expression of cre recombinase would remove both exon 3 and the neo. (J:110050)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:110050
Hara T et al.,
"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice."
Nature 2006 Jun 15;441(7095):885-9
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All: |
25 reference(s)
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Analysis Tools
