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| Nomenclature |
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Symbol:
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Dnmt3btm7Enl
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Name:
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DNA methyltransferase 3B;
targeted mutation 7, En Li
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MGI ID: |
MGI:3628447 |
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Synonyms: |
Dnmt3bG |
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Gene:
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Dnmt3b
Location:
Chr2:153649450-153687730 bp, + strand
Genetic Position: Chr2,
75.79 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:106540
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A targeting vector was designed to insert a D823G substitution. Cre mediated recombination removed a floxed IRES-betageo from the locus. This allele produced protein at levels similar to those of wild-type mice. (J:106540)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dnmt3b Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:106540
Ueda Y et al.,
"Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome."
Development 2006 Mar;133(6):1183-92
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All: |
1 reference(s)
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Analysis Tools
