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| Nomenclature |
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Symbol:
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Ikbkgtm1Mka
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Name:
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inhibitor of kappaB kinase gamma;
targeted mutation 1, Michael Karin
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MGI ID: |
MGI:3620102 |
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Synonyms: |
Ikkgamma-, NEMO- |
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Gene:
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Ikbkg
Location:
ChrX:74393290-74453854 bp, + strand
Genetic Position: ChrX,
38.0 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:63054
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: This allele was created by using one of two vectors. The first vector was designed to insert a beta-lactamase cassette, a stop codon and a neomycin resistance gene in frame with the first ten codons. The second vector was designed to remove most of the coding sequence in the first exon and replace it with a beta-lactamase and neomycin resistance cassette. Western blot failed to detect protein in mutant ES cells. (J:63054)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ikbkg Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:63054
Makris C et al.,
"Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti."
Mol Cell 2000 Jun;5(6):969-79
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All: |
2 reference(s)
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Analysis Tools
