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| Nomenclature |
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Symbol:
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Tg(Pbsn-MYC)6Key
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Name:
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transgene insertion 6, Katharine Ellwood-Yen
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MGI ID: |
MGI:3619445 |
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Synonyms: |
Lo-Myc, PB-Myc-PAI |
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Transgene:
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Tg(Pbsn-MYC)6Key
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Nucleotides -426 through +28 of the rat probasin gene, containing its androgen-inducible, prostate-specific promoter, were joined to a human MYC cDNA flanked by a FLAG epitope coding sequence and the polyadenylation signal from the insulin receptor gene. Immunoblot analysis with an antibody specific for human MYC demonstrates expression in prostate of mice as young as two weeks of age, which increases as the mice approach puberty at approximately 4 weeks. (J:85480)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:85480
Ellwood-Yen K et al.,
"Myc-driven murine prostate cancer shares molecular features with human prostate tumors."
Cancer Cell 2003 Sep;4(3):223-38
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All: |
4 reference(s)
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Analysis Tools
