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| Nomenclature |
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Symbol:
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Sufutm1Rto
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Name:
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suppressor of fused homolog (Drosophila);
targeted mutation 1, Rune Toftgard
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MGI ID: |
MGI:3619046 |
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Synonyms: |
Sufu- |
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Gene:
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Sufu
Location:
Chr19:46396896-46488804 bp, + strand
Genetic Position: Chr19,
38.85 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:105832
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A vector was designed to replace part of the promoter, 5' UTR and first exon, including both transcription and translation start sites, with a neomycin resistance cassette. Northern blot did not detect transcript in mutants and Western blot analysis failed to detect protein. (J:105832)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:105832
Svard J et al.,
"Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway."
Dev Cell 2006 Feb;10(2):187-97
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All: |
5 reference(s)
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Analysis Tools
