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| Nomenclature |
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Symbol:
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Tg(MMTV-PyVT*Y250F)250-2Mul
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Name:
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transgene insertion 250-2, William Muller
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MGI ID: |
MGI:3614339 |
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Synonyms: |
MMTV/MT-Y250F |
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Transgene:
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Tg(MMTV-PyVT*Y250F)250-2Mul
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses mutant plyomavirus middle T antigen with Y to F mutation at position 250 under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. (J:56327)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Total of 8 lines were produced, of which two lines 250-2 and 250-5 had similar phenotype. These mice were used to study metastatic disease and they had similar phenotype.
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| References |
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Original: |
J:56327
Webster MA et al.,
"Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis."
Mol Cell Biol 1998 Apr;18(4):2344-59
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All: |
2 reference(s)
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Analysis Tools
