|
|
| Nomenclature |
|
Symbol:
|
Npm1tm1Ppp
|
|
Name:
|
nucleophosmin 1;
targeted mutation 1, Pier Paolo Pandolfi
|
|
MGI ID: |
MGI:3604807 |
|
Synonyms: |
Npm- |
|
Gene:
|
Npm1
Location:
Chr11:33152287-33163206 bp, - strand
Genetic Position: Chr11,
19.21 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:101494
|
|
Parent Cell Line:
| CJ7 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Reporter) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A targeting vector containing GFP was inserted in-frame with exon 2 at the upstream end, with a modified ACN cassette containing a self-excising neo, resulting in the removal of exons 2-7. GFP was demonstrated to express in the same manner as the endogenous protein. (J:101494)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Npm1 Mutation:
|
17 strains or lines available |
|
|
Notes |
Heterozygous mice exhibit phenotypic similarity to human myelodysplastic syndromes (MDS).
|
| References |
|
Original: |
J:101494
Grisendi S et al.,
"Role of nucleophosmin in embryonic development and tumorigenesis."
Nature 2005 Sep 1;437(7055):147-53
|
|
All: |
4 reference(s)
|
|
Analysis Tools
